Fasting Research: Science, GLP-1 & Expert Analysis

📋 Intermittent Fasting Protocols

16:8 Time-Restricted Eating Most Popular

Schedule: 16h fast, 8h eating window
Example: 12 PM - 8 PM eating
Evidence: Strong (20 studies, 1,288 participants)

OMAD (One Meal A Day)

Schedule: 23h fast, 1h eating
Benefits: Maximum simplicity, deep autophagy
Evidence: Limited

🔬 Clinical Evidence Summary

📊 PMC8839325: Intermittent Fasting and Metabolic Health

Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8839325/ | 66 articles reviewed

Key Finding: IF induces metabolism of fatty acids to ketones, leading to weight decrease and improvements in dyslipidemia and blood pressure.

                📈 Meta-Analysis Results (27 Studies)
                Weight loss range: 0.8% - 13% body weight
Waist circumference: 3-8 cm decrease
            

👨‍⚕️ Expert Opinions

Dr. Jason Fung - "The Obesity Code"

Core Theory: Insulin resistance is the root cause of obesity, not calories.

"The fastest way to dramatically lower your insulin levels is to simply stop eating."

⚖️ 6 Small Meals vs Intermittent Fasting

📊 Head-to-Head Clinical Trial: PMC12310433

Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC12310433/

Study Design: 174 participants, 8 weeks, 25% calorie restriction in both groups

Metric	TRE (16:8)	6 Meals/Day	Winner
Weight Loss	1.17 kg MORE	Baseline	✓ TRE
LDL Reduction	Improved	SUPERIOR	✓ 6 Meals

💉 GLP-1 Agonists: Ozempic, Mounjaro, Wegovy

Drug	Generic	Type	Avg Weight Loss
Ozempic	Semaglutide	GLP-1 agonist	15% body weight
Mounjaro	Tirzepatide	Dual GIP/GLP-1	20%+ body weight

⚠️ Can You Combine Fasting + GLP-1?

Current Recommendation: NOT without medical supervision

Increased side effects: nausea, bloating, circulatory issues
Risk of insufficient nutrient intake

🔬 Active Clinical Trial: NCT07202247

Comparing TRE vs GLP-1 drugs vs combination approach

📊 Summary Comparison

Approach	Weight Loss	Cost	Sustainability
TRE (16:8)	Moderate (5-8%)	FREE	High
6 Meals/Day	Moderate (4-6%)	FREE	Low-Medium
GLP-1 Drugs	High (15-20%)	$$$ ($1000+/mo)	Medium

🧬 Fasting Research Project